The synthesis of functionalized bridged polycycles via C-H bond insertion
Jiun-Le Shih1, Po-An Chen1, Jeremy A May1
1Department of Chemistry, University of Houston, 3585 Cullen Blvd., Fleming Bldg. Room 112, Houston, TX 77204-5003, United States.
Abstract:
This review presents examples from the chemical literature of syntheses of bridged-polycyclic products via C-H bond insertion by carbenes and nitrenes. Applications to natural product synthesis, a description of the essential elements in substrate-controlled reactions, and mechanistic details of transformations are presented. Overall, these transformations allow the construction of important ring systems rapidly and efficiently, though additional catalyst development is needed.
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