Related Experiment Video

Updated: Mar 19, 2026

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke
12:01

PET Imaging of Neuroinflammation Using [11C]DPA-713 in a Mouse Model of Ischemic Stroke

Published on: June 14, 2018

13.3K

TSPO imaging in parkinsonian disorders

Alexander Gerhard1

  • 1Wolfson Molecular Imaging Centre, Institute of Brain, Behaviour and Mental Health, The University of Manchester, 27 Palatine Road, Withington, Manchester, M20 3LJ UK.

Clinical and Translational Imaging
|June 25, 2016
PubMed

Insights

Positron emission tomography (PET) visualizes microglial activation in neurodegenerative diseases like Parkinson's. This technique helps assess treatment effects and develop new imaging agents for neuroinflammation.

Area of Science:

  • Neuroscience
  • Radiochemistry
  • Medical Imaging

Background:

  • Microglial activation is central to neuroinflammation in neurodegenerative disorders, including idiopathic and atypical parkinsonian disorders.
  • Positron emission tomography (PET) enables in vivo imaging of microglial activation, correlating with neuropathological changes.
  • PET has been used to demonstrate the effects of interventions targeting microglial activation in clinical trials.

Approach:

  • Evaluating novel PET tracers for microglial activation with improved properties over [11C]-(R)-PK11195.
  • Developing new PET tracers to target additional neuroinflammatory markers, such as astroglial function.
  • Utilizing advanced imaging techniques to understand the role of neuroinflammation in disease progression.

Key Points:

  • PET imaging reveals distinct patterns of microglial activation in parkinsonian disorders.
  • Interventional studies using PET have shown the efficacy of treatments aimed at reducing neuroinflammation.
  • Ongoing research focuses on developing superior PET tracers for more accurate and comprehensive neuroinflammation assessment.

Conclusions:

  • PET is a valuable tool for studying neuroinflammation in neurodegenerative diseases.
  • Development of new PET tracers will enhance our ability to diagnose and monitor these conditions.
  • Future research will expand imaging capabilities to include other aspects of neuroinflammation, like astroglial function.
Keywords:
MicrogliaNeuroinflammationParkinson’s diseaseTSPO[11C]-(R)-PK11195- PET

More Related Videos

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease16:57

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease

Published on: February 14, 2012

27.0K
Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease06:07

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease

Published on: June 23, 2023

2.4K

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.3K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.3K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
721
Brain Imaging01:14

Brain Imaging

Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
895
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
8.0K
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
351