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Related Experiment Video

Updated: Mar 19, 2026

Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia
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Comparing Longitudinal Behavior Changes in the Primary Progressive Aphasias.

Tim Van Langenhove1,2,3,4, Cristian E Leyton1,2,5, Olivier Piguet1,2,3

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Journal of Alzheimer'S Disease : JAD
|June 25, 2016
PubMed
Summary
This summary is machine-generated.

Semantic PPA (sv-PPA) patients show more frontotemporal dementia-like behaviors early on. Empathy loss helps distinguish nonfluent/agrammatic PPA (nfv-PPA) from logopenic PPA (lv-PPA), aiding in predicting behavioral changes.

Keywords:
Behavioral symptomsempathyfrontotemporal dementialongitudinal studiesprimary progressive aphasia

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Area of Science:

  • Neurology
  • Psychiatry
  • Linguistics

Background:

  • Differentiating primary progressive aphasia (PPA) variants can be challenging due to overlapping language deficits.
  • Longitudinal behavioral changes in PPA variants are not well understood.

Purpose of the Study:

  • To assess behavioral changes in semantic (sv-PPA), nonfluent/agrammatic (nfv-PPA), and logopenic (lv-PPA) variants.
  • To track the progression of these behavioral changes over time.

Main Methods:

  • Behavioral changes were measured in 73 PPA patients (sv-PPA, nfv-PPA, lv-PPA) and compared to behavioral variant frontotemporal dementia (bv-FTD) and Alzheimer's disease (AD) cohorts.
  • The Cambridge Behavioural Inventory Revised was used at baseline and after 1 year in patients with mild dementia severity.

Main Results:

  • sv-PPA patients displayed significantly more bv-FTD-like behavioral disturbances than other PPA variants, evident early and increasing over time.
  • nfv-PPA showed increased empathy loss at follow-up compared to lv-PPA.
  • lv-PPA exhibited behavioral symptoms and progression similar to AD patients.

Conclusions:

  • sv-PPA presents with prominent FTD-like behaviors early in the disease course.
  • Empathy loss is a key differentiator between nfv-PPA and lv-PPA.
  • Findings may improve the prediction of behavioral symptom progression across PPA variants.