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Published on: August 7, 2017
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Circulating periostin level in asthmatic pregnancy.
István Ivancsó1, Anikó Bohács1, Balázs Szalay2
1a Department of Pulmonology , Semmelweis University , Budapest , Hungary.
Summary
Pregnancy increases periostin levels, affecting its use as an asthma biomarker. This study found elevated periostin in healthy and asthmatic pregnant women, impacting asthma control assessments.
Area of Science:
- Reproductive immunology
- Pulmonary medicine
- Biomarker research
Background:
- Asthma complicates pregnancy, posing risks to both mother and fetus.
- Periostin is a known asthma biomarker, but its role in normal pregnancy is unclear.
- Pregnancy may influence circulating periostin levels, complicating its interpretation in asthmatic pregnancies.
Purpose of the Study:
- To investigate plasma periostin levels in pregnant women with asthma.
- To compare periostin levels between asthmatic pregnant women, healthy pregnant women, and non-pregnant controls.
- To evaluate the relationship between periostin levels and asthma control determinants in pregnancy.
Main Methods:
- Plasma periostin levels were measured in four groups: asthmatic non-pregnant (ANP), asthmatic pregnant (AP), healthy non-pregnant (HNP), and healthy pregnant (HP) women.
- Asthma control determinants and lung function (FEV1, Raw) were assessed.
- Receiver operating characteristic (ROC) analysis was used to evaluate diagnostic efficacy.
Main Results:
- Plasma periostin levels were elevated in healthy pregnant (HP) and asthmatic pregnant (AP) women compared to healthy non-pregnant (HNP) controls.
- Periostin levels were similar between healthy pregnant (HP) and asthmatic pregnant (AP) groups.
- In asthmatic pregnant (AP) women, periostin levels negatively correlated with FEV1 and positively with airway resistance (Raw).
Conclusions:
- Pregnancy significantly increases circulating periostin levels, a finding also observed in asthmatic pregnancies.
- While periostin correlates with lung function in asthmatic pregnancy, its utility as an asthma biomarker is limited due to pregnancy-induced elevation.
- Caution is advised when interpreting periostin levels in pregnant patients due to the confounding effect of gestation.
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