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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Label-Free Ultrasensitive Memristive Aptasensor.

Ioulia Tzouvadaki¹, Pawan Jolly², Xiaoling Lu³

¹Integrated System Laboratory, École Polytechnique Fédérale de Lausanne , 1015 Lausanne, Switzerland.

|June 25, 2016

Summary

This summary is machine-generated.

This study introduces a novel electrochemical biosensor using memristive effects and DNA aptamers for ultrasensitive cancer diagnostics. It achieves a record low detection limit for prostate-specific antigen (PSA), paving the way for early cancer detection.

Keywords:

DNA aptamers biosensors cancer diagnosis memristive behavior silicon nanowires

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Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Phthalic Acid Ester-Binding DNA Aptamer Selection, Characterization, and Application to an Electrochemical Aptasensor

Published on: March 21, 2018

Area of Science:

Biomedical Engineering
Nanotechnology
Biosensors

Background:

Early cancer diagnostics are crucial for effective treatment.
Existing biosensors face limitations in sensitivity and detection limits.
Memristive devices offer unique electronic properties for novel sensing applications.

Purpose of the Study:

To develop a novel electrochemical biosensor for cancer diagnostics.
To utilize memristive effects and DNA aptamers for ultrasensitive detection.
To establish a new platform for detecting cancer biomarkers like prostate-specific antigen (PSA).

Main Methods:

Fabrication of memristive silicon nanowires functionalized with DNA aptamers.
Affinity-based detection of PSA using the functionalized nanowires.
Characterization of memristive properties and their response to PSA binding.
Investigation of polyelectrolyte effects on memristive hysteresis.

Main Results:

Demonstrated the first electrochemical biosensor based on memristive effect and DNA aptamers.
Achieved label-free and ultrasensitive detection of PSA.
Reported a record low limit of detection for PSA at 23 aM.
Showcased the influence of charge on memristive hysteresis for biosensing.

Conclusions:

The developed memristive aptamer-based biosensor offers unprecedented ultrasensitivity for cancer marker detection.
This technology holds significant potential for early cancer detection and diagnosis.
The platform can be extended to detect a wide range of cancer biomarkers.