[Hepatotoxic effect of a combination of pyrazinamide with isoniazid and rifampicin]

Experiments on rats showed that 14-day exposure of the animals to pyrazinamide in a dose of 1.5 g/kg induced marked disorders in cholopoiesis and lowering of the reduced glutathion levels in the liver. When pyrazinamide was used in combination with isoniazid or rifampicin a marked increase in the activity of aspartate and alanine aminotransferases in blood serum and induction of lipid peroxidation in the liver were observed in addition to the disorders in cholopoiesis and lowering of the reduced glutathion levels. Combined use of pyraxinamide, isoniazid and rifampicin induced disorders in the liver state not differing significantly from those observed with using pyrazinamide in combination with isoniazid or rifampicin.