Related Experiment Video
Updated: Mar 19, 2026

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Goal-directed therapy and acute kidney injury: as good as it gets?
James F Doyle1, Marlies Ostermann2, Lui G Forni3,4
1Intensive Care Unit and Surrey Perioperative Anaesthesia & Critical Care Collaborative Research Group (SPACeR), Royal Surrey County Hospital NHS Foundation Trust, Egerton Road, Guildford, UK.
Abstract:
The use of goal-directed therapy as part of an enhanced recovery programme is well established in terms of management of the modern high-risk surgical patient in order to reduce both morbidity and mortality. The mechanisms behind this improvement are debated, but a reduction in the development of post-operative complications including acute kidney injury may be relevant. A recent study examining this relationship has been reported and is discussed here.
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