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Updated: Mar 19, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Apixaban to prevent stroke in patients with atrial fibrillation: a review

Benjamin E Peterson1, Sana M Al-Khatib2, Christopher B Granger2

  • 1Duke University Hospital, 2301 Erwin Road, Durham, NC 27710, USA.

Therapeutic Advances in Cardiovascular Disease
|June 26, 2016
PubMed

Insights

Apixaban is a novel oral anticoagulant that effectively prevents stroke in atrial fibrillation patients. It offers superior stroke prevention compared to warfarin with a reduced risk of major bleeding.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Atrial fibrillation (AF) is a prevalent cardiovascular arrhythmia associated with significant morbidity and healthcare costs.
  • Stroke prevention is a critical management goal for patients with atrial fibrillation.
  • Novel oral anticoagulants (NOACs) targeting Factor IIa or Xa have transformed AF treatment.

Purpose of the Study:

  • To review the efficacy and tolerability of apixaban for stroke prevention in atrial fibrillation.
  • To assess the generalizability of apixaban trial findings to broader patient populations.

Main Methods:

  • Review of data from the AVERROES and ARISTOTLE clinical trials.
  • Analysis of secondary trial data and subgroup findings.
  • Evaluation of apixaban's safety and effectiveness profile.

Main Results:

  • Apixaban demonstrated superior stroke prevention compared to warfarin in the general AF population.
  • Apixaban was associated with a significantly lower risk of major bleeding than warfarin.
  • These benefits were observed across various high-risk patient subgroups.

Conclusions:

  • Apixaban is a highly effective and safe anticoagulant for stroke prevention in atrial fibrillation.
  • Apixaban offers advantages over warfarin in both efficacy and safety, including in high-risk populations.

Keywords:
anticoagulationatrial fibrillationstroke

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