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Adult-Onset Hypogonadism.

Mohit Khera1, Gregory A Broderick2, Culley C Carson3

  • 1Baylor College of Medicine, Houston, TX.

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Summary
This summary is machine-generated.

Experts defined adult-onset hypogonadism (AOH) in men with low testosterone and normal/low gonadotropins. This condition presents unique diagnostic and treatment challenges distinct from primary or secondary hypogonadism.

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Area of Science:

  • Andrology
  • Endocrinology
  • Sexual Medicine

Background:

  • Men often present with low testosterone (T) and symptoms, but with normal or low gonadotropins.
  • This presentation doesn't fit classical primary (testicular failure) or secondary (pituitary/hypothalamic failure) hypogonadism.
  • The Sexual Medicine Society of North America (SMSNA) convened experts to address this clinical scenario.

Purpose of the Study:

  • To define and characterize adult-onset hypogonadism (AOH).
  • To differentiate AOH from primary and secondary hypogonadism.
  • To provide a framework for AOH diagnosis, treatment, and monitoring.

Main Methods:

  • An expert colloquium commissioned by the SMSNA in August 2015.
  • A panel of 17 experts in men's health, sexual medicine, urology, and endocrinology.
  • Deliberation on diagnostic processes, T therapy rationale, and patient monitoring protocols.

Main Results:

  • Designation of the syndrome as adult-onset hypogonadism (AOH).
  • Recognition of AOH's distinct characteristics, potentially involving elements of both primary and secondary hypogonadism.
  • Development of recommendations for diagnosis, treatment rationale, and monitoring.

Conclusions:

  • AOH is a common condition in middle-aged and older men.
  • Understanding AOH is crucial for healthcare professionals.
  • This document provides a conceptual framework to guide the evaluation and management of AOH.