Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

2.2K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.2K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.8K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

Reduced-Dose Post-Transplant Cyclophosphamide as Graft-Versus-Host Disease Prophylaxis in Matched Donor Allogeneic Stem Cell Transplantation: A Systematic Review of Efficacy and Toxicity.

Transplantation and cellular therapy·2026
Same author

Infections Within 100 Days of Idecabtagene Vicleucel and Impact on Survival for Relapsed/Refractory Multiple Myeloma: A CIBMTR Analysis.

Transplantation and cellular therapy·2026
Same author

Comparison of Fludarabine Versus Bendamustine as a Lymphodepleting Chemotherapy Prior to CAR-T for Large Cell Lymphoma.

Transplantation and cellular therapy·2026
Same author

A phase-variable capsule facilitates <i>Akkermansia muciniphila</i> colonization of the intestinal mucus layer.

mBio·2026
Same author

Prolonged Cytopenia After Idecabtagene Vicleucel for Multiple Myeloma is Associated with Poor Overall Survival.

Transplantation and cellular therapy·2026

Related Experiment Video

Updated: Mar 19, 2026

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

2.0K

Infection Rates among Acute Leukemia Patients Receiving Alternative Donor Hematopoietic Cell Transplantation.

Karen Ballen1, Kwang Woo Ahn2, Min Chen3

  • 1Division of Hematology/Oncology, Massachusetts General Hospital, Boston, Massachusetts.

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
|June 26, 2016
PubMed
Summary

Hematopoietic cell transplantation (HCT) using alternative graft sources like umbilical cord blood (UCB) or unrelated donors (MUD/MMUD) shows varied infection risks. Umbilical cord blood and mismatched unrelated donors had higher bacterial and viral infection rates compared to matched unrelated donors.

Keywords:
InfectionLeukemiaUmbilical cord blood

More Related Videos

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

4.6K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.6K

Related Experiment Videos

Last Updated: Mar 19, 2026

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
03:40

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

2.0K
Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis
06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

4.6K
Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice
10:02

Intra-Peritoneal Transplantation for Generating Acute Myeloid Leukemia in Mice

Published on: January 6, 2023

2.6K

Area of Science:

  • Hematology
  • Infectious Diseases
  • Transplantation Medicine

Background:

  • Hematopoietic cell transplantation (HCT) offers a curative option for acute leukemia patients lacking matched sibling donors.
  • Alternative graft sources, including umbilical cord blood (UCB), matched unrelated donors (MUD), and mismatched unrelated donors (MMUD), are increasingly utilized.
  • While overall outcomes are comparable, the comparative risks of infection across these graft sources remain understudied.

Purpose of the Study:

  • To compare the incidence and types of bacterial, viral, and fungal infections following alternative donor HCT.
  • To identify specific graft sources associated with higher infection risks in adult acute leukemia patients.
  • To inform clinical decision-making regarding graft source selection based on infection profiles.

Main Methods:

  • Retrospective analysis of 1781 adult patients with acute leukemia undergoing alternative donor HCT between 2008 and 2011.
  • Categorization of graft sources into UCB (n=568), MUD (n=930), and MMUD (n=283).
  • Comparison of 1-year incidences of bacterial, viral, and fungal infections, with multivariable analysis to adjust for confounding factors.

Main Results:

  • Higher incidences of bacterial (72% vs 59% vs 65%) and viral (68% vs 45% vs 53%) infections at 1 year were observed in UCB, MUD, and MMUD groups, respectively.
  • Multivariable analysis revealed significantly higher rates of bacterial, fungal, and viral infections with UCB and MMUD compared to MUD.
  • UCB also showed higher rates of bacterial and viral infections than MMUD. Bacterial and fungal infections were linked to poorer overall survival.

Conclusions:

  • Umbilical cord blood and mismatched unrelated donor grafts are associated with increased risks of bacterial and viral infections post-HCT compared to matched unrelated donors.
  • Targeted infection prevention and treatment strategies are crucial for improving outcomes in patients receiving alternative donor HCT.
  • Graft source selection should consider the differential infection risks to optimize patient management and survival.