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Oxytocin in cesarean-sections. What's new?

Eduardo Tsuyoshi Yamaguchi1, Mônica Maria Siaulys2, Marcelo Luis Abramides Torres3

  • 1Hospital Universitário da Universidade de São Paulo (HU-USP), São Paulo, SP, Brazil.

Brazilian Journal of Anesthesiology (Elsevier)
|June 26, 2016
PubMed

Oxytocin is the uterotonic agent of choice in the prevention and treatment of postpartum uterine atony. Nevertheless, there is no consensus on the optimal dose and rate for use in cesarean sections. The use of high bolus doses (e.g., 10IU of oxytocin) can determine deleterious cardiovascular changes for the patient, especially in situations of hypovolemia or low cardiac reserve. Furthermore, high doses of oxytocin for prolonged periods may lead to desensitization of oxytocin receptors in myometrium, resulting in clinical inefficiency.

Keywords:
Cesarean sectionCesarianaDesensitizationDessensibilizaçãoDoseOcitocinaOxytocin

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