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Related Concept Videos

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Related Experiment Video

Updated: Mar 18, 2026

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
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Do human B-lymphocytes avoid aging until 60 years?

Andrea Knight1,2, Pavel Nemec1, Sona Bretzova1,3

  • 1Department of Pathological Physiology, Faculty of Medicine, Masaryk University Brno, Brno, Czech Republic.

Oncotarget
|June 27, 2016
PubMed
Summary

B cells maintain their molecular integrity until age 60, suggesting hematopoietic stem cells generate uncompromised lymphocytes in early elderly. This indicates immunity may not require intervention in younger elderly individuals.

Keywords:
B cellGEPGerotargetIL7Ragingnaive B cells

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Area of Science:

  • Immunology
  • Gerontology
  • Molecular Biology

Background:

  • Advanced age is linked to significant alterations in human innate and adaptive immunity.
  • Age-related changes in gene expression have been observed in both T and B lymphocytes.

Purpose of the Study:

  • To investigate genome-wide gene expression profiles in naive and whole B cell populations from young and early-aged healthy donors.
  • To determine if significant gene deregulation occurs in B cells between the ages of 30-45 and 50-60.

Main Methods:

  • Analysis of genome-wide expression profiles from 20 healthy donors (young: 30-45 years; early aged: 50-60 years).
  • Comparison of gene expression patterns between young and early-aged B cell populations.

Main Results:

  • High homogeneity was observed across all analyzed genome-wide expression profiles.
  • No significant gene deregulation was identified in B cells from early-aged donors compared to young donors.

Conclusions:

  • B cells appear to resist the molecular aging process until approximately 60 years of age.
  • Hematopoietic stem cells can generate uncompromised lymphocytes in the early elderly.
  • Immunity maintenance in this age group may not necessitate intervention for naive B cells, but further research on older individuals is warranted.