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3D MRI-based multicomponent thin layer structure only plaque models for atherosclerotic plaques.

Xueying Huang1, Chun Yang2, Jie Zheng3

  • 1School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, China; Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computation, Xiamen University, Xiamen, Fujian 361005 China; Department of Mathematical Sciences, Worcester Polytechnic Institute, MA 01609, USA.

Journal of Biomechanics
|June 27, 2016
PubMed
Summary

A new 3D thin-layer structure only (TLS) plaque model approximates 3D fluid-structure interaction (FSI) models for atherosclerotic plaques. This faster TLS model shows high correlation with FSI results, aiding clinical implementation for cardiovascular disease risk assessment.

Keywords:
Fluid-structure interactionsStressThin layer structure only modelVulnerable atherosclerotic plaques

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Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Computational Mechanics

Background:

  • Fluid-structure interaction (FSI) models analyze atherosclerotic plaque mechanics and plaque wall stress (PWS) in cardiovascular disease.
  • Current 3D FSI model construction is time-consuming, limiting clinical application.

Purpose of the Study:

  • To develop a computationally efficient 3D thin-layer structure only (TLS) plaque model as an approximation to 3D FSI models.
  • To assess the accuracy and clinical potential of the TLS model for atherosclerotic plaque analysis.

Main Methods:

  • 192 TLS models were created from 192 ex vivo MRI images of 12 human coronary atherosclerotic plaques.
  • Plaque stresses were extracted, and maximum (MPWS) and average (APWS) plaque wall stress values were compared between TLS and FSI models.

Main Results:

  • The TLS model demonstrated low relative errors for MPWS (9.76%) and APWS (9.89%) compared to FSI models.
  • Both MPWS and APWS values from TLS models showed strong correlation and consistent results with 3D FSI models.

Conclusions:

  • The proposed 3D TLS plaque model serves as a viable, computationally inexpensive approximation to 3D FSI models.
  • With further validation, TLS models could potentially replace FSI models, accelerating mechanical analysis of atherosclerotic plaques for clinical use.