Flexible Substrate-Based Devices for Point-of-Care Diagnostics.
ShuQi Wang1, Thiruppathiraja Chinnasamy2, Mark A Lifson2
1State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang Province, 310003, China; Institute for Translational Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310029, China; Bio-Acoustic MEMS in Medicine (BAMM) Laboratory, Canary Center at Stanford for Cancer Early Detection, Department of Radiology, Stanford University, School of Medicine, Palo Alto, CA 94304, USA.
Flexible substrates like paper and polymers are advancing point-of-care (POC) diagnostics for better healthcare. These materials enable new diagnostic devices for personalized health monitoring and disease surveillance.
Area of Science:
- Biomedical Engineering
- Materials Science
- Clinical Diagnostics
Background:
- Point-of-care (POC) diagnostics are crucial for healthcare delivery, clinical management, and disease surveillance globally.
- Current POC diagnostics predominantly use paper substrates due to cost-effectiveness and mass production feasibility.
- Flexible polymer substrates offer improved properties and integration potential for advanced diagnostic applications.
Purpose of the Study:
- To review recent advancements in flexible substrate-based diagnostic devices.
- To highlight the clinical applications of both paper and polymer-based POC diagnostics.
- To discuss the potential of these substrates in personalized health monitoring and wearable technology.
Main Methods:
- Literature review of recent research on flexible substrate materials for diagnostics.
- Analysis of the properties and advantages of paper and polymer substrates.
- Examination of current and emerging clinical applications of flexible substrate diagnostics.
Main Results:
- Flexible polymer substrates show promise for enhanced POC diagnostic devices.
- Integration with wearable technology and wireless communication is a key development area.
- Customization of flexible substrates allows for tailored POC diagnostic solutions.
Conclusions:
- Flexible substrates, including polymers, are significantly impacting the development of next-generation POC diagnostics.
- These advancements facilitate personalized health monitoring and improved disease management.
- The versatility of flexible substrates supports diverse clinical applications and future innovations.
