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Updated: Mar 18, 2026

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
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[Use of prostatic specific antigen in primary care (PSA)]
J Panach-Navarrete1, A Gironés-Montagud1, E Sánchez-Cano1
1Servicio de Urología, Hospital Clínico Universitario de Valencia, Valencia, España.
Semergen
|June 27, 2016
Summary
Primary care physicians often misuse prostate-specific antigen (PSA) testing, requesting it too early or too frequently. Many doctors doubt PSA
Area of Science:
- Urology
- Primary Care Medicine
- Medical Diagnostics
Background:
- Prostate-specific antigen (PSA) testing is sometimes misused in clinical practice.
- Guidelines for appropriate PSA testing, considering patient age and frequency, are not always followed.
Purpose of the Study:
- To describe the current use of PSA testing by primary care physicians.
- To analyze factors influencing PSA testing, including patient age and physician beliefs.
- To compare PSA testing practices and beliefs between physicians with and without sufficient knowledge.
Main Methods:
- A descriptive and comparative study utilizing questionnaires distributed to primary care doctors.
- Statistical analysis, including the Chi-squared test, was used to compare groups.
Main Results:
- 83.5% of physicians reported sufficient PSA knowledge, yet this group ordered tests more frequently and at earlier ages.
- Physicians with less knowledge requested PSA at older ages and expressed more doubts about its utility.
- Nearly 30% of physicians believe PSA is unhelpful in cancer diagnosis, and 28% would never order it without urinary symptoms.
Conclusions:
- A significant portion of primary care physicians express doubts about PSA's utility in prostate cancer diagnosis.
- Inconsistent PSA testing practices, including frequency and patient selection, were observed.
- Physicians lacking sufficient PSA knowledge exhibited less appropriate testing patterns and lower perceived utility of the marker.
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