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Bile: miRNA pattern and protein-based biomarkers may predict acute cellular rejection after liver transplantation
Rosa Bianca Schmuck1, Anja Reutzel-Selke1, Nathanael Raschzok1
1a General, Visceral and Transplantation Surgery, Experimental Surgery and Regenerative Medicine , Charité - Universitätsmedizin Berlin , Campus Virchow Klinikum , Berlin , Germany.
Context:
Bile rather than blood depicts the local inflammation in the liver and may improve prediction and diagnosis of acute cellular rejection (ACR) after liver transplantation (OLT).
Methods:
Secretome and miRNAs were analyzed during the first two weeks and on clinical suspicion of ACR in the bile of 45 OLT recipients.
Results:
Levels of CD44, CXCL9, miR-122, miR-133a, miR-148a and miR-194 were significantly higher in bile of patients who developed ACR within the first 6 months after OLT and during ACR.
Conclusion:
Analysis of secretome and miRNA in bile could improve our understanding of the local inflammatory process during rejection.
