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Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function.

Hyo Youl Moon¹, Andreas Becke², David Berron²

¹Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224, USA.

Cell Metabolism

|June 28, 2016

Summary

This summary is machine-generated.

Exercise benefits the brain through muscle-secreted cathepsin B (CTSB). Running increases CTSB, which enhances neurogenesis and memory. This protein links physical activity to cognitive function in humans and animals.

Keywords:

cathepsin B exercise hippocampus humans memory mice muscle

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Area of Science:

Exercise physiology
Neuroscience
Molecular biology

Background:

The mechanisms linking physical activity to brain health are not fully understood.
Peripheral factors, particularly those secreted by muscles, may play a crucial role in mediating exercise's cognitive benefits.

Purpose of the Study:

To investigate the role of muscle-secreted factors in exercise-induced cognitive and neurogenic benefits.
To identify specific proteins involved in mediating the effects of exercise on brain function.

Main Methods:

Proteomic analysis of skeletal muscle cell cultures treated with AICAR.
Measurement of cathepsin B (CTSB) levels in mouse muscle and plasma after running.
In vitro studies on adult hippocampal progenitor cells treated with recombinant CTSB.
Assessment of neurogenesis and spatial memory in CTSB knockout mice.
Analysis of CTSB levels in plasma of Rhesus monkeys and humans after exercise.

Main Results:

Cathepsin B (CTSB) protein levels were elevated in muscle cells treated with AICAR.
Running increased CTSB levels in mouse gastrocnemius muscle and plasma.
Recombinant CTSB enhanced expression of BDNF and DCX in hippocampal progenitor cells via P11.
CTSB knockout mice did not show enhanced neurogenesis or memory after running.
Treadmill exercise increased plasma CTSB in Rhesus monkeys and humans, correlating with fitness and memory.

Conclusions:

Cathepsin B (CTSB) is a muscle-secreted factor that mediates the cognitive and neurogenic benefits of exercise.
CTSB plays a key role in enhancing adult hippocampal neurogenesis and spatial memory.
Plasma CTSB levels may serve as a biomarker for exercise-induced cognitive improvements in humans.