Related Experiment Video

Updated: Mar 18, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K

Vitamin D Status in Infants with Two Different Wheezing Phenotypes

Ali Ozdemir1, Dilek Dogruel2, Ozlem Yilmaz3

  • 1Pediatric Pulmonary Section, Department of Pediatrics, Mersin Children's Hospital, Halkkent, 33240, Mersin, Turkey. aliozdemir@hotmail.com.

Indian Journal of Pediatrics
|June 28, 2016
PubMed

Insights

Infants with recurrent wheeze, regardless of Asthma Predictive Index status, show lower vitamin D levels. Vitamin D deficiency is more prevalent in these infants, suggesting a potential role in recurrent wheezing development.

Area of Science:

  • Pediatrics
  • Nutritional Science
  • Respiratory Medicine

Background:

  • Recurrent wheeze is a common respiratory issue in early childhood.
  • Vitamin D plays a crucial role in immune system regulation.
  • Understanding factors contributing to recurrent wheeze is vital for early intervention.

Purpose of the Study:

  • To investigate serum vitamin D levels in infants diagnosed with recurrent wheeze.
  • To compare vitamin D status between infants with different recurrent wheeze phenotypes (API positive vs. negative) and healthy controls.

Main Methods:

  • A cross-sectional study involving 186 infants with recurrent wheezing and 118 healthy controls.
  • Serum 25-hydroxy vitamin D [25(OH)D] levels were measured as an indicator of vitamin D adequacy.
  • Infants with recurrent wheeze were categorized based on Asthma Predictive Index (API) positivity.

Main Results:

  • Infants with recurrent wheeze exhibited significantly lower mean serum 25(OH)D levels compared to healthy controls (p < 0.05).
  • The API-negative group had the lowest mean vitamin D level (22.71 ± 10.76 ng/ml), followed by the API-positive group (24.08 ± 9.02 ng/ml).
  • Vitamin D deficiency was more prevalent in both API-negative (52.1%) and API-positive (38.5%) infants compared to controls (31.4%).

Conclusions:

  • Low serum 25(OH)D levels are detected in infants presenting with recurrent wheezing, irrespective of API status.
  • Vitamin D deficiency may be implicated in the pathogenesis of recurrent wheezing in infants.
  • Further research is warranted to explore the therapeutic potential of vitamin D supplementation.
Abstract

Keywords:
Allergic sentisizationAsthma predictive indexRecurrent wheezingVitamin D

More Related Videos

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K
Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

44.2K

Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.8K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K
Pedigree Analysis01:35

Pedigree Analysis

Overview
90.5K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.7K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
3.3K