Related Experiment Video

Updated: Mar 18, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
10:27

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts

Published on: July 25, 2020

8.1K

Application of post-genomic techniques in dog cancer research

F Ceciliani1, P Roccabianca1, C Giudice1

  • 1Department of Veterinary Medicine, Università di Milano, Via Celoria 02, 20133 Milano, Italy. fabrizio.ceciliani@unimi.it.

Molecular Biosystems
|June 28, 2016
PubMed

Insights

This review highlights recent advances in applying omics techniques like transcriptomics, proteomics, and metabolomics to canine cancer research. It also covers methods for analyzing formalin-fixed tissues and the potential for biomarker discovery in veterinary diagnostics.

Area of Science:

  • Veterinary Science
  • Canine Oncology
  • Genomics

Background:

  • Omics techniques are underutilized in canine cancer research compared to farm animals and infectious diseases.
  • Existing research primarily focuses on farm animal production and infectious disease applications of omics.

Purpose of the Study:

  • To review recent achievements in applying postgenomic techniques to canine cancer research.
  • To present protocols for omics analysis of formalin-fixed, paraffin-embedded tissues.
  • To highlight the potential of omics for biomarker discovery and cancer diagnostics in veterinary medicine.

Main Methods:

  • Review of recent literature on omics applications in canine cancer.
  • Description of protocols for sample preparation from formalin-fixed, paraffin-embedded tissues for transcriptomics, proteomics, and metabolomics.
  • Discussion of biomarker discovery and diagnostic potential.

Main Results:

  • Omics methodologies are emerging as valuable tools in canine cancer research.
  • Protocols for utilizing archival formalin-fixed, paraffin-embedded tissues for omics analyses are feasible.
  • Significant potential exists for omics-driven biomarker discovery for canine cancer diagnostics.

Conclusions:

  • The application of omics techniques in canine oncology is rapidly advancing.
  • Standardized protocols will facilitate wider adoption of omics in veterinary cancer research.
  • Omics-based biomarkers hold promise for improving canine cancer diagnosis and treatment.

More Related Videos

Comparative Lesions Analysis Through a Targeted Sequencing Approach08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

7.3K
Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

12.3K

Related Concept Videos

The Central Dogma01:20

The Central Dogma

The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
35.1K