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Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Updated: Mar 18, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
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DNA Damage and Aging Around the Clock.

Paula Gutierrez-Martinez1, Derrick J Rossi2, Isabel Beerman1

  • 1Program in Cellular and Molecular Medicine, Division of Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Trends in Molecular Medicine
|June 28, 2016
PubMed
Summary
This summary is machine-generated.

Aging hematopoietic stem cells show altered DNA damage response and lymphoid gene expression. The circadian rhythm gene Per2 is implicated in these age-related changes.

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Area of Science:

  • Hematology
  • Molecular Biology
  • Chronobiology

Background:

  • Aging significantly impacts the hematopoietic system.
  • The molecular mechanisms driving these age-related hematopoietic changes remain largely unknown.

Purpose of the Study:

  • To investigate the role of circadian rhythm genes in the aging hematopoietic system.
  • To explore the function of the Per2 gene in aged hematopoietic stem cells.

Main Methods:

  • Analysis of gene expression in aged hematopoietic stem cells.
  • Investigating the DNA damage response pathways.

Main Results:

  • The circadian rhythm gene Per2 was found to be involved in the DNA damage response.
  • Per2 influences the expression of lymphoid genes in aged hematopoietic stem cells.

Conclusions:

  • The circadian gene Per2 plays a role in the molecular mechanisms of hematopoietic aging.
  • Targeting Per2 may offer therapeutic strategies for age-related hematopoietic dysfunction.