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11:01
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
[Diethylpentenamide, a substitute for carbromal? (author's transl)]
Deutsche Medizinische Wochenschrift (1946)
|July 21, 1978
Summary
Diethylpentenamide, a non-prescription drug, was used in four suicide attempts, causing severe respiratory depression. Treatment involved extracorporeal detoxication, successfully saving the patients. One patient experienced acute pancreatitis.
Area of Science:
- Toxicology
- Pharmacology
Background:
- Bromcarbamide-containing sleeping pills are associated with fatal intoxications and suicide attempts.
- Diethylpentenamide, a chemically related drug, was available without prescription since 1975 in the German Federal Republic.
Observation:
- Four cases of attempted suicide using diethylpentenamide are reported.
- Clinical signs observed were similar to those seen in carbromal intoxication.
- Severe respiratory depression was a prominent symptom.
Findings:
- Extracorporeal detoxication, utilizing combined haemoperfusion and haemodialysis, proved effective in treating the severe respiratory depression.
- One patient developed acute pancreatitis as a complication of the intoxication.
Implications:
- Diethylpentenamide overdose can lead to life-threatening respiratory depression requiring intensive medical intervention.
- The findings highlight the potential dangers of non-prescription drugs and the efficacy of extracorporeal detoxication methods.
- Further research into the toxicological profile and management of diethylpentenamide overdose is warranted.
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