Related Experiment Video
Updated: Mar 18, 2026
In Vitro Generation of Heart Field-specific Cardiac Progenitor Cells
Published on: July 3, 2019
Generation of iPSC from cardiac and tail-tip fibroblasts derived from a second heart field reporter mouse
Javier Linares1, Estibaliz Arellano-Viera1, Olalla Iglesias-García1
1Cell Therapy Program, Center for Applied Medical Research (CIMA), University of Navarra, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
Abstract:
Mef2c Anterior Heart Field (AHF) enhancer is activated during embryonic heart development and it is expressed in multipotent cardiovascular progenitors (CVP) giving rise to endothelial and myocardial components of the outflow tract, right ventricle and ventricular septum. Here we have generated iPSC from transgenic Mef2c-AHF-Cre x Ai6(RCLZsGreen) mice. These iPSC will provide a novel tool to investigate the AHF-CVP and their cell progeny.
