Related Experiment Video
Updated: Aug 19, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
[Bile excretion system in endogenous hypercorticism syndrome]
Abstract:
Bile excretion and biochemical properties of bile were investigated in 86 patients with the endogenic hypercorticism syndrome, 78 patients with the Itsenko-Cushing disease and in 8 patients with corticosteroma. A considerable incidence of functional and organic biliary disorders was demonstrated. Changes in cholecyst contractility were recorded in 54.6% of the patients, with hypermotor dyskinesia (36.4%) prevailing. An excess of endogenic corticosteroids was frequently accompanied by a hypotonus of Oddi's sphincter (65.6%) or Lutkens' sphincter (67.2%). Chronic (stoneless) cholecystitis was diagnosed in 70.9% of the patients, cholelithiasis, in 16.3%, and cholecyst cholesterosis, in 3.5%. Adrenocortical hyperfunction was associated with natural changes in biochemical composition of the bile, such as excessive cholesterol and a relative deficiency of cholic acid and phospholipids which might be conducive to cholelithiasis. High incidence of biliary disturbances and their pattern should be taken into account in the treatment of patients with hypercorticism.
Related Concept Videos
Drug Elimination: Non-Renal Routes
Hepatic Drug Excretion: Enterohepatic Cycling
Post-release drugs and metabolites can be reabsorbed into the body from the intestine. For conjugated metabolites like glucuronides, reabsorption requires enzymatic hydrolysis by intestinal microflora. This...
Hepatic Drug Excretion: Influencing Factors
Drug Excretion: Miscellaneous Routes
Cushing Syndrome I: Introduction
Cushing Syndrome II: Pathophysiology

