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Updated: Mar 18, 2026

LAD-Ligation: A Murine Model of Myocardial Infarction
Published on: October 14, 2009
The Role of ADAMTS1 and Versican in Human Myocardial Infarction: A Postmortem Study
Sultan Pehlivan1, Murat Serdar Gurses2, Mustafa Numan Ural2
1Morgue Department, Ankara Regional Office of Council of Forensic Medicine, Ankara, Turkey, drspehlivan@hotmail.com.
Objective:
To determine the role of a disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1) and fragmented versican in the myocardial infarction (MI) process in humans and to evaluate the diagnostic efficacy of ADAMTS1 for postmortem diagnosis of MI.
Methods:
Thirty autopsied individuals were allocated into 2 groups, namely, a study group of individuals who died of myocardial infarction (n = 20), and a control group who died of trauma (n = 10). We performed standard immunohistochemical staining on myocardial tissue specimens, studying anti-ADAMTS1, anti-versican, and anti-versican C terminal peptide sequence (DPEAAE) fragments.
Results:
Strong, diffuse staining was observed throughout myocardial tissue for ADAMTS1 in the 2 groups. However, in the study group, we observed no expression for ADAMTS1 around fibrotic areas but detected slight staining in coagulative and necrotic zones.
Conclusion:
Similar localizations of ADAMTS and fragmented versican in human heart tissue indicate that versican presumably is cleaved by ADAMTS1. Hence, ADAMTS1 can be regarded as a new marker for postmortem differential diagnosis of MI.
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