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A reference interval study for common biochemical analytes in Eastern Turkey: a comparison of a reference population
Ebubekir Bakan1, Harun Polat1, Yesim Ozarda2
1Department of Medical Biochemistry, Ataturk University, School of Medicine, Erzurum, Turkey.
Biochemia Medica
|June 28, 2016
Summary
This study establishes regional reference intervals (RIs) for 34 analytes in Northeast Turkey, highlighting differences between direct and indirect methods and with existing national data. These findings are crucial for accurate clinical interpretation in the region.
Area of Science:
- Clinical Chemistry
- Biochemistry
- Population Health
Background:
- Establishing accurate reference intervals (RIs) is vital for interpreting laboratory test results.
- Previous studies on RIs in Turkey have not fully captured regional variations.
- Nutritional and environmental factors may influence analyte levels within a population.
Purpose of the Study:
- To define region-specific reference intervals (RIs) for 34 analytes in a Turkish population from Northeast Turkey (Erzurum).
- To compare RIs obtained using direct and indirect methods.
- To compare the derived RIs with nationwide and previous Turkish RI studies.
Main Methods:
- Direct method: Analysis of 435 blood samples from healthy individuals (18-65 years) using Roche reagents and analyzers.
- Indirect method: Calculation of RIs using data from 1,366,948 records via a modified Bhattacharya method.
- Analyzed 34 different analytes in serum samples.
Main Results:
- Significant gender-based differences were observed for 17 analytes.
- Discrepancies noted between direct and indirect RIs for analytes including gamma-glutamyltransferase, creatine kinase, LDL-cholesterol, and iron.
- Direct method RIs showed comparability with some nationwide/previous Turkish studies but significant differences with kit insert values for analytes like AST, total cholesterol, HDL-cholesterol, and vitamin B12.
Conclusions:
- The study provides essential region-specific reference intervals for 34 analytes using both direct and indirect methods.
- Observed variations in RIs underscore the importance of regional specificity, potentially influenced by nutritional and environmental factors.
- These region-specific RIs aid in more accurate clinical diagnostics for the studied Turkish population.
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