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Delayed kidney injury following coronary angiography

Feng Wang1, Cheng Peng2, Guangyuan Zhang3

  • 1Department of Nephrology and Rheumatology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, P.R. China.

Experimental and Therapeutic Medicine
|June 28, 2016
PubMed

Insights

Delayed kidney injury (DKI) after coronary angiography (CAG) affects 7.1% of patients. Anemia, heart failure, and high-dose aspirin are identified risk factors for this delayed kidney injury.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Delayed kidney injury (DKI), also known as delayed contrast-induced nephropathy (CIN), can occur 1-6 months post-coronary angiography (CAG).
  • Understanding the risk factors and pathogenesis of DKI is crucial for patient management.

Purpose of the Study:

  • To investigate the risk factors associated with delayed kidney injury (DKI) following coronary angiography (CAG).
  • To explore the potential pathogenesis of delayed kidney injury (DKI).

Main Methods:

  • Retrospective analysis of 436 patients undergoing CAG or coronary stenting between January 2008 and December 2009.
  • Comparison of clinical characteristics and treatment data between patients who developed DKI and those who did not.

Main Results:

  • The incidence of DKI was 7.1% (31/436).
  • Patients with DKI had lower hemoglobin, lower estimated glomerular filtration rate (eGFR), higher serum creatinine, higher rates of heart failure, and were more likely to be on 300 mg aspirin therapy.
  • Anemia, heart failure, and 300 mg aspirin intake were identified as significant risk factors for DKI.

Conclusions:

  • Heart dysfunction and 300 mg aspirin therapy are potential contributors to delayed kidney injury (DKI) after coronary angiography (CAG).
  • Iodinated contrast media administration itself was not found to be a risk factor for DKI.

Keywords:
acute kidney injuryaspirincontrast-induced nephropathycoronary angiographyheart failure

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