Related Experiment Video
Updated: Mar 18, 2026
04:33
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
1.6K
Patient-reported functioning in major depressive disorder
Waguih William IsHak1, David M James2, James Mirocha2
1Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, 8730 Alden Drive, Thalians E-132, Los Angeles, CA 90048, USA.
Therapeutic Advances in Chronic Disease
|June 28, 2016
Summary
Major depressive disorder (MDD) treatment improves functioning, but most patients still experience deficits. Functioning declines post-treatment, especially for non-remitted patients, highlighting the need for personalized interventions.
Area of Science:
- Psychiatry
- Clinical Psychology
- Neuroscience
Background:
- Major depressive disorder (MDD) significantly impairs patient functioning beyond symptom resolution.
- Assessing functional outcomes is crucial for evaluating comprehensive treatment effectiveness.
Purpose of the Study:
- To examine the impact of MDD and its treatment on patient functioning.
- To evaluate functional recovery rates at different treatment stages and post-treatment follow-up.
Main Methods:
- Analysis of 2280 adult outpatients with MDD from the STAR*D trial.
- Functioning assessed using the Work and Social Adjustment Scale (WSAS) at entry, exit, and 12-month follow-up.
Main Results:
- Only 7% of patients reported normal functioning pre-treatment.
- Treatment increased functioning, but over 60% remained impaired at exit.
- Functioning declined at 12-month follow-up, particularly in non-remitted patients.
Conclusions:
- Functional outcomes are critical in MDD treatment.
- Current treatments inadequately restore functioning for many patients.
- Personalized interventions are needed to improve long-term functioning in MDD.
Related Concept Videos
01:27Depressive Disorders: MDD and Dysthymia
1.0K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.0K
01:18Depression: Overview
1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
01:05Long-term Depression
33.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.6K
01:03Long-term Depression
3.5K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.5K
01:27Depressive Disorders: Etiology
834
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
834
01:27Diagnostic and Statistical Manual of Mental Disorders (DSM)
1.5K
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
1.5K