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Prohibitin: an unexpected role in sex dimorphic functions
K Hoa Nguyen1, Sudharsana R Ande1, Suresh Mishra1,2
1Department of Internal Medicine, John Buhler Research Centre, University of Manitoba, Rm 843, 715 McDermot Avenue, Winnipeg, Manitoba R3E 3P4 Canada.
Biology of Sex Differences
|June 28, 2016
Summary
Prohibitin (PHB) plays a key role in sex differences in fat and immune cell functions. This protein may interact with sex hormones to influence these sexually dimorphic processes.
Area of Science:
- Endocrinology and immunology
- Molecular biology
- Obesity research
Background:
- Sex differences in adipose and immune functions are influenced by sex steroid hormones.
- The specific proteins mediating these sex differences, particularly in adipose-immune interactions, are not well understood.
Purpose of the Study:
- To investigate the role of prohibitin (PHB) in mediating sex differences in adipose and immune functions.
- To explore the potential interplay between PHB, sex steroid hormones, and sexually dimorphic adipose-immune interactions.
Main Methods:
- Utilized two novel obese mouse models (Mito-Ob and m-Mito-Ob).
- Analyzed the function of prohibitin (PHB) in the context of sex differences.
Main Results:
- Identified an unexpected role for prohibitin (PHB) in sex differences observed in adipose and immune functions.
- Demonstrated that PHB is involved in sexually dimorphic adipose-immune interactions.
Conclusions:
- Pleiotropic proteins like prohibitin (PHB) are crucial in mediating sex differences in adipose and immune functions.
- PHB may interact with sex steroid hormones to regulate sexually dimorphic adipose-immune crosstalk.