Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

barbieQ: an R software package for analysing barcode count data from clonal tracking experiments.

Bioinformatics (Oxford, England)·2026
Same author

Single-cell profiling of BAL in preschool cystic fibrosis reveals macrophage dysregulation and ivacaftor-modified inflammatory programs in the early life lung.

Mucosal immunology·2026
Same author

Non-apoptotic caspase-8 is critical for orchestrating exaggerated inflammation during severe SARS-CoV-2 infection.

Nature communications·2025
Same author

Effects of CVA21, an Oncolytic Virus, in Combination with Pembrolizumab on Immunogenicity and the Tumor Microenvironment in Advanced NSCLC: A Phase I/II Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Variant scoring tools for deep mutational scanning.

Molecular systems biology·2025
Same author

A systematic benchmark of Nanopore long-read RNA sequencing for transcript-level analysis in human cell lines.

Nature methods·2025
Same journal

Sentiment Analysis of Acceptance TVET Online Courses on the Skill Academy App from Google Play: Leveraging Text Mining with Comparison Machine Learning Model.

F1000Research·2026
Same journal

Emotional intelligence: An important skill to learn now more than ever.

F1000Research·2026
Same journal

East Mediterranean Lineage of <i>Brucella melitensis</i> in Human Isolates and Milk Samples in Oman Using MLVA-14.

F1000Research·2026
Same journal

Application of K-Means Clustering for Job Applicant Analysis in Construction Firms Using R.

F1000Research·2026
Same journal

The influence of self-esteem and emotional intelligence on addiction to social networks in Peruvian university students.

F1000Research·2026
Same journal

A Bibliometric Analysis of Music's Role in Promoting Well-Being in Health Science Research.

F1000Research·2026
See all related articles

Related Experiment Video

Updated: Mar 18, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K

A cross-package Bioconductor workflow for analysing methylation array data.

Jovana Maksimovic1, Belinda Phipson1, Alicia Oshlack1,2,3

  • 1Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.

F1000Research
|April 26, 2017
PubMed
Summary
This summary is machine-generated.

This study presents a Bioconductor workflow for analyzing human genome methylation array data. The workflow covers quality control, normalization, and differential methylation analysis, aiding research in development and disease.

Keywords:
arraybioconductormethylationworkflow

More Related Videos

Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

14.0K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Related Experiment Videos

Last Updated: Mar 18, 2026

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
14:56

Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies

Published on: May 6, 2022

5.3K
Methodology for Accurate Detection of Mitochondrial DNA Methylation
12:11

Methodology for Accurate Detection of Mitochondrial DNA Methylation

Published on: May 20, 2018

14.0K
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

6.2K

Area of Science:

  • Genomics
  • Epigenetics
  • Bioinformatics

Background:

  • DNA methylation is crucial for human development and disease.
  • Illumina Infinium methylation arrays are widely used for genome-wide methylation analysis.

Purpose of the Study:

  • To provide a comprehensive Bioconductor workflow for analyzing methylation array data.
  • To detail steps for differential methylation analysis and related epigenetic studies.

Main Methods:

  • Utilized Bioconductor packages for a robust analysis pipeline.
  • Implemented quality control, filtering, and normalization techniques.
  • Performed statistical testing for probe-wise and regional differential methylation.

Main Results:

  • Demonstrated a complete workflow for differential methylation analysis.
  • Outlined methods for differential variability, cell type estimation, and gene ontology testing.
  • Provided examples for visualizing methylation array data.

Conclusions:

  • The presented workflow facilitates efficient and comprehensive analysis of methylation array data.
  • This resource supports research into the roles of DNA methylation in biological processes and diseases.