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Diversity of Protists II

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Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Recent advances in understanding apicomplexan parasites.

Frank Seeber¹, Svenja Steinfelder²

¹FG16: Mycotic and parasitic agents and mycobacteria, Robert Koch-Institute, Berlin, Germany.

|June 28, 2016

Summary

Recent advances illuminate Apicomplexa parasite biology, host interactions, and drug resistance mechanisms. New insights into effector proteins, metabolism, and stable transfection of Cryptosporidium offer therapeutic and research opportunities.

Keywords:

Apicomplexa CRISPR/Cas9 Plasmodium T. gondii parasites

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Last Updated: Mar 18, 2026

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

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Published on: November 22, 2024

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Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Selection of Plasmodium falciparum Parasites for Cytoadhesion to Human Brain Endothelial Cells

Published on: January 3, 2012

Area of Science:

Parasitology
Molecular Biology
Immunology

Background:

Apicomplexa are prevalent intracellular parasites causing significant global morbidity.
Emerging drug resistance in Plasmodium falciparum (malaria) necessitates understanding resistance mechanisms.
Apicomplexa manipulate host cells and evade immune responses via secreted effector proteins.

Purpose of the Study:

To review recent advances in Apicomplexa biology, host-pathogen interactions, and therapeutic strategies.
To highlight new findings on drug resistance, host cell manipulation, and immune evasion.
To discuss methodological breakthroughs enabling further research.

Main Methods:

Review of recent scientific literature.
Analysis of studies on drug resistance mechanisms in Plasmodium.
Investigation of molecular mechanisms of host cell manipulation and immune evasion by Toxoplasma, Theileria, and Plasmodium.
Application of metabolomics and molecular biology techniques.
Development of stable transfection methods for Cryptosporidium.

Main Results:

Advances in understanding artemisinin resistance in Plasmodium falciparum.
Elucidation of molecular mechanisms for effector protein trafficking and host cell immortalization.
New insights into how secreted proteins affect innate immune responses.
Progress in unraveling mitochondrial carbon metabolism.
Successful generation of stably transfected Cryptosporidium parasites.

Conclusions:

Recent research has significantly advanced our understanding of Apicomplexa biology and host interactions.
New knowledge on drug resistance and host manipulation offers potential for novel therapeutic interventions.
Methodological innovations, particularly in Cryptosporidium research, open new avenues for studying these important pathogens.