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Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
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Hepatitis01:25

Hepatitis

6
Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.4K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
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Related Experiment Video

Updated: Mar 18, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
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Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

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The changing faces of cholangitis.

Sum P Lee1, Joseph R Roberts1, Rahul Kuver1

  • 1Department of Medicine, Division of Gastroenterology , University of Washington School of Medicine, Seattle, WA, USA.

F1000Research
|June 28, 2016
PubMed
Summary

Cholangitis encompasses diverse hepatobiliary diseases, including autoimmune and infectious types. Recent research advances offer new insights into cholangitis pathophysiology, diagnosis, and treatment strategies.

Keywords:
IgG4-associated sclerosing cholangitischolangitischolangitis researchprimary biliary cholangitisprimary sclerosing cholangitis

Related Experiment Videos

Last Updated: Mar 18, 2026

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

55.1K

Area of Science:

  • Hepatology and immunology, focusing on biliary tract diseases.

Background:

  • Cholangitis is a group of hepatobiliary diseases with varied causes, including autoimmune conditions like primary sclerosing cholangitis and primary biliary cholangitis, as well as infectious etiologies such as bacterial cholangitis and liver fluke-associated cholangitis.
  • Understanding the pathophysiologic basis of these disorders is crucial for effective management.

Purpose of the Study:

  • To review recent advances in cholangitis research.
  • To highlight novel insights into the pathophysiology, diagnosis, and treatment of diverse cholangitis disorders, with a focus on autoimmune conditions.

Main Methods:

  • Literature review of selected advances in cholangitis research.
  • Focus on studies elucidating pathophysiologic mechanisms, diagnostic improvements, and therapeutic refinements.

Main Results:

  • Advances in understanding autoimmune cholangitis pathogenesis.
  • Improved diagnostic and prognostic capabilities for cholangitis.
  • Opportunities for refining and reimagining treatment modalities for various cholangitis types.

Conclusions:

  • Recent research provides novel insights into the complex pathophysiology of cholangitis.
  • These advances are improving diagnostic accuracy and patient prognostication.
  • The findings pave the way for developing more effective and targeted treatment strategies for cholangitis.