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Qing'E formula alleviates the aging process in D-galactose-induced aging mice
Lin Zhong1, Fei Huang1, Hailian Shi1
1Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China.
Biomedical Reports
|June 28, 2016
Summary
Qing
Area of Science:
- Gerontology and Traditional Chinese Medicine
- Pharmacology and Toxicology
Background:
- Qing'E formula (QEF) is a traditional Chinese medicine prescription used clinically.
- Aging is associated with cognitive and motor decline, as well as oxidative stress.
Purpose of the Study:
- To investigate the anti-aging effects of QEF in a D-galactose-induced aging mouse model.
- To elucidate the underlying mechanisms of QEF's anti-aging properties.
Main Methods:
- An aging mouse model was induced using D-galactose injections over 8 weeks.
- Motor activity and memory were assessed using rotarod and passive avoidance tests.
- Biochemical analyses of serum and liver, and molecular analysis of hippocampal gene and protein expression were performed.
Main Results:
- QEF significantly improved motor activity and memory in aging mice.
- QEF demonstrated protective effects on renal and hepatic function, reducing oxidative stress markers (nitric oxide and malondialdehyde).
- QEF modulated the expression of longevity-related genes (Klotho, SIRT1) and proteins in the hippocampus.
Conclusions:
- QEF exhibits significant anti-aging effects in a mouse model of induced aging.
- Mechanisms include enhanced antioxidant capacity, protection of renal and hepatic health, and regulation of hippocampal longevity pathways.
- QEF holds potential for mitigating age-related decline.
