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Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

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Novel Starch-PVA Polymer for Microparticle Preparation and Optimization Using Factorial Design Study.

Helen Chattopadhyay¹, Amit Kumar De¹, Sriparna Datta¹

¹Department of Chemical Technology, University of Calcutta, 92 A.P.C. Road, Kolkata 700 009, India.

International Scholarly Research Notices

|June 28, 2016

Summary

This study optimized a novel starch-polyvinyl alcohol (PVA) polymer for controlled Ornidazole delivery. The developed microparticles exhibited desirable characteristics for effective drug release.

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Area of Science:

Materials Science
Pharmaceutical Technology
Polymer Chemistry

Background:

Controlled drug delivery systems are crucial for therapeutic efficacy.
Novel polymer formulations are needed to improve drug release profiles.
Starch-polyvinyl alcohol (PVA) presents a promising biodegradable option.

Purpose of the Study:

To optimize the ratio of a novel starch-polyvinyl alcohol (PVA) polymer for controlled Ornidazole delivery.
To prepare and characterize Ornidazole-loaded microparticles using this polymer.
To investigate the influence of polymer concentration on drug release kinetics.

Main Methods:

Polymer-coated drug microparticles were prepared via an emulsion method.
Microscopic analyses (SEM, AFM) characterized microparticle size and morphology.
Fourier transform infrared spectroscopy (FTIR) assessed drug-polymer interactions.
A 3(2) full factorial design analyzed the impact of starch and PVA concentrations on drug release.

Main Results:

Microparticles were uniformly spherical with sizes under 10 micrometers.
SEM and AFM confirmed smooth surfaces and spherical morphology.
FTIR indicated no adverse drug-polymer interactions.
Factorial design and 3D plots elucidated the effect of polymer concentrations on release kinetics.

Conclusions:

The novel starch-PVA polymer is suitable for developing controlled drug delivery systems.
Optimized polymer ratios enable tailored Ornidazole release profiles.
This formulation holds potential for targeted drug delivery applications.