Association between Serum Bilirubin and Estimated Glomerular Filtration Rate among Diabetic Patients

The subjects comprised 230 men aged 77 ± 10 (range: 50-100) years and 279 women aged 81 ± 10 (50-101) years that visited the medical department. We examined the relationship between increased serum bilirubin and renal function evaluated by estimated glomerular filtration rate (eGFR) using CKD-EPI equations modified by a Japanese coefficient. Compared with the fourth quartile in serum bilirubin (1.01-1.97 mg/dL), the nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios {95% confidence interval (CI)} of eGFR <60 mL/min/1.73 m(2) for the first quartile in serum bilirubin (0.13-0.50 mg/dL) were 2.08 (1.25-3.44), 1.82 (1.07-3.09), and 1.53 (0.83-2.81), respectively. Moreover, compared with the fourth quartile, nonadjusted, age and gender-adjusted, and multivariate-adjusted odds ratios (95% CI) of eGFR <45 mL/min/1.73 m(2) for the first quartile were 3.50 (1.95-6.23), 3.12 (1.72-5.65), and 3.53 (1.71-7.26), respectively. The data were further stratified by gender, age, medication (antihypertensive, antidyslipidemic, and antidiabetic agents), and prevalence of cardiovascular disease (CVD). The standardized coefficients for eGFR were significant in all the subgroups other than the prevalence of CVD, and there were significant interactions between the two groups regarding CVD. Our data demonstrated an independent positive association between serum bilirubin and eGFR among diabetic patients.