Organocatalytic enantioselective desymmetrisation

Area of Science:

• Organic Chemistry
• Asymmetric Synthesis

Background:

• Organocatalytic enantioselective desymmetrisation is crucial for synthesizing complex molecules.
• This method offers an alternative to metal- or enzyme-catalyzed reactions.
• Recent years show significant growth in organocatalyst applications for desymmetrisation.

Purpose of the Study:

• To provide a comprehensive overview of enantioselective desymmetrisation using organocatalysts since 2010.
• To highlight practical applications and the sophistication of this synthetic strategy.
• To inform the broader synthetic chemistry community about recent advancements.

Main Methods:

• Review of literature published since 2010.
• Focus on organocatalytic enantioselective desymmetrisation reactions.
• Analysis of methodologies for achiral and meso compounds.

Main Results:

• Demonstration of organocatalysis as a powerful tool in desymmetrisation.
• Showcasing the construction of enantiomerically enriched molecules with multiple stereocentres.
• Highlighting high selectivities achieved in these transformations.

Conclusions:

• Organocatalysis has emerged as a leading strategy for enantioselective desymmetrisation.
• The field has witnessed substantial progress, offering elegant solutions for complex molecule synthesis.
• This review underscores the value and accessibility of organocatalytic desymmetrisation.