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Updated: Mar 18, 2026

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
Published on: August 25, 2019
Next generation sequencing: Improved resolution for paternal/maternal duos analysis
Yan Ma1, Jin-Zhi Kuang1, Tong-Gang Nie1
1Institute of Forensic Science, Tianjin Public Security Bureau, Tianjin 300384, China.
Abstract:
In the case of two mismatches observed in alleged parent-offspring pairs, there is doubt as to whether there is an exclusion of the putative parent or the existence of two mutations. Here, we report on four cases with two mismatches in paternal/maternal duos based on capillary electrophoresis (CE) results. The analyzed next generation sequencing (NGS) results were compared with 20 autosomal STRs derived from previous CE-based analysis. In summary, the NGS samples used offered comprehensive information of different types of markers that can improve resolutions for paternal/maternal duos analysis.
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