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Androgens.

Rakesh Iyer, David J Handelsman

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    Summary
    This summary is machine-generated.

    Androgen abuse, a prevalent form of sports doping, has spread from elite athletes to recreational users. Detecting this performance-enhancing drug abuse requires ongoing scientific innovation and vigilance.

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    Area of Science:

    • Sports Science
    • Pharmacology
    • Criminology

    Background:

    • Androgen abuse is the most significant form of detected sports doping, originating during the Cold War.
    • It has evolved from elite power sports to recreational use for cosmetic purposes.
    • Both direct (androgen administration) and indirect (boosting testosterone) abuse methods are prevalent.

    Purpose of the Study:

    • To analyze the evolution and current landscape of androgen abuse in sports and recreational settings.
    • To highlight the challenges in detecting and preventing androgen doping.
    • To emphasize the need for advanced anti-doping strategies.

    Main Methods:

    • Review of historical and current trends in androgen abuse.
    • Analysis of detection methods, primarily mass spectrometry-based urine tests.
    • Discussion of the socio-cultural drivers for androgen abuse.

    Main Results:

    • Androgen abuse has transitioned from elite sports to widespread recreational use.
    • Current anti-doping tests are effective but face challenges from evolving abuse methods.
    • The recreational aspect of androgen abuse is largely unrecognized and unaddressed.

    Conclusions:

    • Continued scientific innovation and vigilance are crucial to combat evolving androgen doping in elite sports.
    • Coaches and athletes must be targeted to build resilience against doping.
    • Effective strategies for addressing recreational androgen abuse are urgently needed.