Related Experiment Video
Updated: Mar 18, 2026

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
Published on: March 1, 2024
Justicidin B: A Promising Bioactive Lignan
Shiva Hemmati1,2, Hassan Seradj3
1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran. hemmatish@sums.ac.ir.
Abstract:
Adverse effects and drug resistance to the current onchopharmacologicals have increased the demand for alternative novel therapeutics. We herein introduce justicidin B, an arylnaphthalen lignan isolated from different plant origins, especially Justicia, Phyllanthus, Haplophyllum and Linum species. This cyclolignan exhibits a wide array of biological properties ranges from piscicidal to antifungal, antiviral and antibacterial activities. Activity against Trypanosoma brucei makes justicidin B a potential antiprotozoal agent for the treatment of neglected tropical diseases. Pharmacological properties like antiplatelet, anti-inflammatory and bone resorption inhibition have been also attributed to justicidin B. This compound is a potent cytotoxic substance on several cell lines, especially chronic myeloid and chronic lymphoid leukemia. Pharmacological values, natural variation, as well as biotechnological production of justicidin B by plant cell, tissue and organ culture are also described in this review. Chemical characteristics and chromatographic methods to identify justicidin B and its biosynthetic pathway have been discussed. Different approaches to the total synthesis of justicidin B are compared. This review would shed light on the role of justicidin B as an intriguing natural compound and provides a chance to optimize conditions for industrial applications.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Gene Regulation in Microbial Communities: Quorum Sensing
Inhibitors of Bacterial Protein Synthesis
Dipeptidyl Peptidase 4 Inhibitors
Antifungal Agents
TGF - β Signaling Pathway

