Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

7
Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These...
7
Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

845
Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
845
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

14
Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...
14
Dipeptidyl Peptidase 4 Inhibitors01:23

Dipeptidyl Peptidase 4 Inhibitors

934
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
934
Antifungal Agents01:15

Antifungal Agents

1
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
1
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

10.9K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The NeuroImmunoEndocrine Circuit of Umami Peptides: A Systems Biology Approach.

Nutrients·2026
Same author

Cytokines, chemokines, and immune cells involved in oral immunity towards the dental cariogenic bacterium Streptococcus mutans: Therapeutic interventions and vaccination.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Toward the Development of a Biosimilar Variant of Glucarpidase (Carboxypeptidase G2): Secretory Production, Optimization, and Immobilization.

Molecular biotechnology·2025
Same author

Expanding the cryoprotectant toolbox in biomedicine by multifunctional antifreeze peptides.

Biotechnology advances·2025
Same author

The Roadmap of Plant Antimicrobial Peptides Under Environmental Stress: From Farm to Bedside.

Probiotics and antimicrobial proteins·2024
Same author

Molecular docking studies, DFT, and ADMET calculations of some flavonoids and their characteristic structural features involved in inhibition of pro-inflammatory enzymes.

Natural product research·2024

Related Experiment Video

Updated: Mar 18, 2026

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

1.5K

Justicidin B: A Promising Bioactive Lignan.

Shiva Hemmati1,2, Hassan Seradj3

  • 1Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, P. O. Box 71345-1583 Shiraz, Iran. hemmatish@sums.ac.ir.

Molecules (Basel, Switzerland)
|June 28, 2016
PubMed
Summary

Justicidin B, a natural compound from plants, shows broad biological activities including potential treatments for neglected tropical diseases and cancer. Its diverse pharmacological properties and biotechnological production are reviewed for industrial applications.

Keywords:
arylnaphthalenebiological activitybiosynthesisbiotechnological productionchemistrychromatographydistributionjusticidin Blignansynthesis

More Related Videos

Lignin Down-regulation of Zea mays via dsRNAi and Klason Lignin Analysis
14:43

Lignin Down-regulation of Zea mays via dsRNAi and Klason Lignin Analysis

Published on: July 23, 2014

14.0K
Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
09:22

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

7.7K

Related Experiment Videos

Last Updated: Mar 18, 2026

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

1.5K
Lignin Down-regulation of Zea mays via dsRNAi and Klason Lignin Analysis
14:43

Lignin Down-regulation of Zea mays via dsRNAi and Klason Lignin Analysis

Published on: July 23, 2014

14.0K
Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues
09:22

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

7.7K

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Biotechnology

Background:

  • Current onchopharmacological treatments face challenges due to adverse effects and drug resistance.
  • There is a growing need for novel therapeutic agents.
  • Justicidin B, an arylnaphthalen lignan from various plant species, is a promising candidate.

Purpose of the Study:

  • To review the diverse biological and pharmacological properties of justicidin B.
  • To explore its potential as a therapeutic agent for various diseases.
  • To discuss its biotechnological production and synthetic approaches.

Main Methods:

  • Literature review of studies on justicidin B.
  • Analysis of its isolation from plant sources.
  • Comparison of different total synthesis strategies.

Main Results:

  • Justicidin B exhibits a wide range of activities: piscicidal, antifungal, antiviral, antibacterial, and antiprotozoal (against Trypanosoma brucei).
  • It possesses antiplatelet, anti-inflammatory, and bone resorption inhibitory properties.
  • The compound shows potent cytotoxicity against leukemia cell lines (chronic myeloid and lymphoid).

Conclusions:

  • Justicidin B is a versatile natural compound with significant therapeutic potential for neglected tropical diseases and cancer.
  • Its natural variation, biotechnological production, and synthetic routes are crucial for optimizing industrial applications.
  • Further research into justicidin B could lead to novel drug development.