Mechanisms of Zika Virus Infection and Neuropathogenesis
David Olagnier1, Michela Muscolini2, Carolyn B Coyne3
11 Lady Davis Institute, Jewish General Hospital, McGill University , Montreal, Canada .
Abstract:
A spotlight has been focused on the mosquito-borne Zika virus (ZIKV) because of its epidemic outbreak in Brazil and Latin America, as well as the severe neurological manifestations of microcephaly and Guillain-Barré syndrome associated with infection. In this review, we discuss the recent literature on ZIKV-host interactions, including new mechanistic insight concerning the basis of ZIKV-induced neuropathogenesis.
Insights
Zika virus (ZIKV) outbreaks cause severe neurological issues like microcephaly. This review explores ZIKV-host interactions and the mechanisms behind ZIKV-induced brain damage.
Area of Science:
- Virology
- Neuroscience
- Epidemiology
Background:
- The mosquito-borne Zika virus (ZIKV) gained global attention due to its epidemic in Brazil and Latin America.
- ZIKV infection is linked to severe neurological conditions, notably microcephaly in infants and Guillain-Barré syndrome in adults.
Purpose of the Study:
- To review recent literature on Zika virus-host interactions.
- To provide mechanistic insights into ZIKV-induced neuropathogenesis.
Main Methods:
- Literature review of recent studies on ZIKV.
- Analysis of research on ZIKV-host interactions and neuropathogenesis.
Main Results:
- Recent literature highlights complex ZIKV-host interactions.
- Emerging mechanistic insights into how ZIKV affects the nervous system.
Conclusions:
- Understanding ZIKV-host interactions is crucial for addressing neuropathogenesis.
- Further research is needed to elucidate the mechanisms of ZIKV-induced neurological damage.
