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[Systemic lupus erythematosus and pregnancy].

P Schwarz, P Halberg

    Ugeskrift for Laeger
    |April 24, 1989
    PubMed
    Summary

    Pregnancies in women with systemic lupus erythematosus (SLE) show higher rates of premature birth and fetal loss compared to the general population. Active SLE disease increases the risk of exacerbation during pregnancy.

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    Experimental gerontology·2020

    Area of Science:

    • Rheumatology
    • Obstetrics
    • Immunology

    Context:

    • Systemic lupus erythematosus (SLE) poses significant risks during pregnancy.
    • Previous literature on SLE pregnancies is reviewed to assess outcomes and risks.

    Purpose:

    • To review and synthesize data on pregnancy outcomes in patients with SLE.
    • To identify risk factors for adverse pregnancy outcomes and maternal complications.

    Summary:

    • A review of 1,164 pregnancies in SLE patients revealed 54% normal outcomes, 15% premature births, and 29% fetal wastage, contrasting with general population rates.
    • Maternal SLE exacerbations occurred in about one-third of patients, particularly in the last trimester or postpartum. Active disease at conception doubled exacerbation risk.
    • Cardiolipin-antibody and Ro-antibody may serve as markers for fetal wastage and neonatal heart block, respectively.

    Impact:

    • Informs current clinical practice regarding the management of SLE patients considering pregnancy.
    • Highlights the importance of patient counseling on risks, including exacerbation, fetal wastage, and premature delivery.
    • Suggests postponing pregnancy for SLE patients with active disease until remission is achieved.

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