Related Experiment Video
Updated: Mar 18, 2026
07:26
Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
13.5K
Self-Assembly of Peptide Bioconjugates: Selected Recent Research Highlights
Ian W Hamley1, Valeria Castelletto1
1Department of Chemistry, University of Reading , Whiteknights, Reading, RG6 6AD, United Kingdom.
Bioconjugate Chemistry
|June 28, 2016
Summary
Recent research highlights self-assembling peptide amphiphiles (PAs) and polymer-peptide conjugates. Advances include new chemistries, bioactivity relationships, composites, and high-throughput design for sequenced peptides.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Supramolecular Chemistry
Background:
- Self-assembling peptide amphiphiles (PAs) and polymer-peptide conjugates are advanced biomaterials.
- Understanding their self-assembly is crucial for developing new applications.
Purpose of the Study:
- To review recent advancements in peptide amphiphile and polymer-peptide conjugate research.
- To highlight key developments in synthesis, self-assembly, and applications.
Main Methods:
- Literature review of recent research.
- Focus on new polymer chemistries, self-assembly kinetics, and bioactivity.
- Exploration of composite materials and enzymatic tuning.
Main Results:
- New polymer chemistries enable novel conjugate synthesis.
- Self-assembly landscapes and kinetics are increasingly understood.
- Bioactivity is directly linked to self-assembly properties.
- Enzymatic methods and high-throughput screening accelerate design.
Conclusions:
- Peptide amphiphiles and conjugates offer versatile platforms for advanced materials.
- Continued research promises enhanced control over self-assembly and tailored bioactivity.
- These materials hold significant potential in various biomedical applications.
Related Concept Videos
02:41Protein Complex Assembly
17.0K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types. Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Many viruses self-assemble into a fully functional unit using the infected host cell to...
17.0K
02:43Peptide Bonds
85.8K
A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
85.8K
01:30Assembly of Signaling Complexes
7.0K
Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
7.0K
01:25Protein Folding
12.1K
Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
12.1K