Supramolecular Recognition of Amino Acids by Twisted Cucurbit[14]uril
Jing Zhang1, Yun-Yun Xi1, Qing Li1
1Key Laboratory of Macrocyclic and Supramolecular Chemistry of Guizhou Province, Department of Chemistry, Guizhou University, Guiyang, 550025, China.
Abstract:
Binding interactions between twisted cucurbit[14]uril (tQ[14]) and twenty standard amino acids (AAs) have been investigated by NMR spectroscopy and isothermal titration calorimetry (ITC) in aqueous HCl solutions and in DMSO. The results showed that tQ[14] displays clear binding affinity for AAs with a positively charged side chain or containing an aromatic ring, but weaker binding affinity for AAs with hydrophobic or polar side chains, with the binding mode depending on the type of side chain present in the AAs.
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