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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
Published on: August 28, 2012
MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?
Kévin Baranger1, Michel Khrestchatisky1, Santiago Rivera2
1Aix Marseille Univ, CNRS, NICN, Marseille, France.
Journal of Neuroinflammation
|June 29, 2016
Summary
We identified membrane-type 5-MMP (MT5-MMP) in Alzheimer's disease (AD) models. This enzyme processes amyloid precursor protein (APP) and may worsen AD through inflammation and altered APP transport.
Area of Science:
- Neuroscience
- Biochemistry
- Molecular Biology
Background:
- Alzheimer's disease (AD) pathogenesis involves amyloid precursor protein (APP) processing.
- The role of specific proteases in AD is an area of active research.
Purpose of the Study:
- To investigate the role of membrane-type 5-MMP (MT5-MMP) in Alzheimer's disease (AD).
- To explore potential mechanisms by which MT5-MMP contributes to AD pathogenesis beyond APP processing.
Main Methods:
- Utilized a transgenic mouse model of Alzheimer's disease (AD).
- Investigated the enzymatic activity of MT5-MMP on amyloid precursor protein (APP).
- Examined the potential involvement of inflammatory pathways and APP trafficking.
Main Results:
- MT5-MMP was identified as a new factor in AD pathogenesis.
- MT5-MMP exhibits pro-amyloidogenic properties and processes APP.
- APP processing by MT5-MMP may release a neurotoxic fragment.
- Hypothesized complementary roles for MT5-MMP in activating inflammation and altering APP trafficking.
Conclusions:
- MT5-MMP is implicated in Alzheimer's disease (AD) pathogenesis.
- MT5-MMP's role extends beyond direct APP processing, potentially involving inflammatory responses and APP transport.
- Further research is warranted to elucidate the full impact of MT5-MMP in AD.
Keywords:
Amyloid precursor proteinAmyloidogenesisIL-1βMatrix metalloproteinasesNeurodegenerative diseaseNeuroinflammationTraffickingMore Related Videos
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