Related Experiment Video
Updated: Mar 18, 2026
Multilevel Microdissection and Functional-Structural Profiling of Human Renal Arterial Branches
Published on: September 5, 2025
Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men
Kaori Nakanishi1, Makoto Nishida1, Ryohei Yamamoto1
1Health Care Center, Osaka University, Toyonaka, Osaka, Japan.
Background:
The natriuretic peptides, brain natriuretic peptide (BNP) and N-terminal-proBNP (NT-proBNP), are cardiac-derived hormones and can serve as biomarkers for ventricular dysfunction. BNP has cardio-protective effects and is known as a regulator of metabolism. In the present study, to evaluate the relationship between natriuretic peptides and metabolic disorders, we focused on the association between NT-proBNP and metabolic syndrome-related molecule adiponectin (APN).
Methods:
Forty-five apparently healthy men who underwent health examination at the Osaka University Health Care Center were enrolled for this study. Physical and biochemical parameters including serum APN and NT-proBNP concentrations were obtained from all the subjects.
Results:
The serum concentrations of NT-proBNP negatively correlated with metabolic disorder parameters, body mass index (BMI), waist circumferences, and fasting plasma glucose levels, but positively correlated with APN, suggesting that similar to APN, NT-proBNP is associated with metabolic disorders. Furthermore, increased serum concentrations of APN were found to be accompanied by increased serum concentrations of NT-proBNP and decreased BMI and mean intima-media thickness.
Conclusions:
The serum concentrations of NT-proBNP are associated with APN concentrations and metabolic disorder parameters in healthy subjects.
More Related Videos
11:36A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
08:41Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Published on: June 3, 2019
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Regulation of Food Intake
01:17Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
01:27Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
01:26Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...