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Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
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Rewiring macrophages for anti-tumour immunity
1Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), #04 Immunos, 8A Biomedical Grove, Singapore 138648.
Nature Cell Biology
|June 29, 2016
Abstract:
Tumour-associated macrophages facilitate cancer progression, but whether they can be reprogrammed to elicit an anti-tumour response remains unclear. Deletion of the microRNA-processing enzyme Dicer is now shown to rewire macrophages to an anti-tumour mode, leading to an enhanced response to immunotherapy and inhibition of tumour progression.
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