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Proteinuria and progression of pediatric chronic kidney disease: lessons from recent clinical studies

Sahar A Fathallah-Shaykh1

  • 1Department of Pediatrics, Division of Nephrology, University of Alabama at Birmingham, 516 Lowder Building, 1600 7th Avenue South, Birmingham, AL, 35233, USA. sfathallah@peds.uab.edu.

Pediatric Nephrology (Berlin, Germany)
|June 29, 2016
PubMed

Insights

Proteinuria, or protein in urine, is common in children with chronic kidney disease (CKD). Studies show it worsens kidney function, but more research is needed to confirm its impact and find treatments.

Area of Science:

  • Pediatric Nephrology
  • Clinical Research Methodology

Background:

  • Proteinuria is a common finding in pediatric chronic kidney disease (CKD), with causes differing from adult populations.
  • The relationship between proteinuria and CKD progression has been investigated through various clinical studies.

Purpose of the Study:

  • To review and analyze existing clinical studies on the influence of proteinuria on the progression of chronic kidney disease in children.
  • To evaluate the strengths and weaknesses of retrospective and prospective studies examining proteinuria in pediatric CKD.

Main Methods:

  • Systematic review and synthesis of findings from retrospective and prospective clinical studies.
  • Analysis of studies focusing on both glomerular and congenital causes of CKD in children.

Main Results:

  • Retrospective studies in children with CKD corroborate findings from adult studies, linking proteinuria to declining kidney function.
  • Prospective studies have further investigated the impact of proteinuria on kidney function decline and end-stage kidney disease risk.

Conclusions:

  • Current evidence, while significant, has limitations necessitating further investigation.
  • Large-scale clinical trials are required to definitively establish the influence of proteinuria on pediatric CKD progression and to develop effective interventions.

Keywords:
ChildrenChronic kidney diseaseClinical trialsProgressionProteinuria

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