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Development and Statistical Optimisation of Buspirone Hydrochloride Buccoadhesive Films
Upendra Nagaich1, Vandana Chaudhary2, Jaya Nagaich3
1Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh 201313, India.
International Scholarly Research Notices
|June 29, 2016
Summary
This study developed optimized buspirone hydrochloride buccal films using hydroxypropylmethylcellulose and Eudragit RL-100. The stable films demonstrated effective drug release and diffusion, confirming successful formulation.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Buccal drug delivery offers an alternative route for systemic administration, bypassing first-pass metabolism.
- Buspirone hydrochloride is an anxiolytic agent requiring effective delivery for therapeutic outcomes.
Purpose of the Study:
- To prepare and optimize unidirectional buccal films of buspirone hydrochloride.
- To evaluate the influence of polymer composition and plasticizer on film properties and drug release.
Main Methods:
- Solvent casting technique was employed for film preparation.
- Hydroxypropylmethylcellulose (HPMC K15M) and Eudragit RL-100 were used as polymers.
- Polyethylene glycol 400 and sodium lauryl sulphate served as plasticizer and permeation enhancer.
- Statistical optimization identified two promising formulations (OF1 and OF2).
Main Results:
- Optimized formulations exhibited physicochemical properties consistent with predicted values.
- In-vitro drug release and ex-vivo diffusion studies demonstrated effective drug permeation.
- Stability studies confirmed the integrity of the buccal films under various conditions.
Conclusions:
- Statistically optimized unidirectional buccal films of buspirone hydrochloride were successfully developed.
- The developed films show potential for effective buccal drug delivery.
- The formulations exhibited good stability and drug release profiles.
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