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Related Concept Videos

RNA Splicing01:32

RNA Splicing

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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Alternative RNA Splicing02:18

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Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
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In eukaryotic cells, transcripts made by RNA polymerase are modified and processed before exiting the nucleus. Unprocessed RNA is called precursor mRNA or pre-mRNA to distinguish it from mature mRNA.
Once about 20-40 ribonucleotides have been joined together by RNA polymerase, a group of enzymes adds a “cap” to the 5’ end of the growing transcript. In this process, a 5’ phosphate is replaced by modified guanosine that has a methyl group attached to it (7-Methyl...
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Using the E1A Minigene Tool to Study mRNA Splicing Changes
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m(6)A: Signaling for mRNA splicing.

Samir Adhikari1, Wen Xiao1, Yong-Liang Zhao2

  • 1a Key Laboratory of Genomic and Precision Medicine , Collaborative Innovation Center of Genetics and Development, CAS Center for Excellence in Molecular Cell Science, University of Chinese Academy of Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing , China.

RNA Biology
|June 29, 2016
PubMed
Summary

N6-methyladenosine (m(6)A) is a key RNA modification regulating gene expression. This study investigates the nuclear reader YTHDC1, focusing on its role in alternative splicing and RNA metabolism.

Keywords:
Alternative splicingSRSF10SRSF3YTHDC1m6A

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • RNA Biology

Background:

  • N6-methyladenosine (m(6)A) is a prevalent dynamic RNA modification in eukaryotes.
  • m(6)A regulates diverse biological processes, including development and cell reprogramming.
  • YTH domain-containing proteins are the primary readers of m(6)A modifications.

Purpose of the Study:

  • To investigate the function of the nuclear m(6)A reader, YTHDC1.
  • To elucidate the regulatory role of YTHDC1 in alternative splicing.
  • To explore YTHDC1's involvement in other RNA metabolic processes.

Main Methods:

  • Focus on the nuclear m(6)A reader YTHDC1.
  • Analysis of YTHDC1's role in alternative splicing.
  • Investigation of YTHDC1 in RNA metabolism.

Main Results:

  • YTHDC1 plays a crucial role in regulating alternative splicing.
  • YTHDC1 is involved in various RNA metabolic pathways.
  • Detailed mechanisms of YTHDC1's function are explored.

Conclusions:

  • YTHDC1 is a key regulator of RNA processing.
  • Understanding YTHDC1's function provides insights into gene expression control.
  • Further research on m(6)A readers like YTHDC1 is essential for RNA biology.