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Published on: March 30, 2018
Three Rwandan Children With Massive Splenomegaly and Epstein-Barr Virus-associated Lymphoproliferative Disorders:
DeAnna Friedman-Klabanoff1, Allison Ball, Samuel Rutare
1*Department of Pediatrics, School of Medicine, Duke University, Durham, NC†Department of Pediatrics, Geisel School of Medicine, Dartmouth College, Hanover, NH‡Department of Pediatrics, Kigali University Teaching Hospital, Kigali, Rwanda§Department of Pediatrics, School of Medicine, Yale University, New Haven, CT∥Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Abstract:
This report describes 3 Rwandan children with massive splenomegaly and pancytopenia who underwent splenectomy. Each was diagnosed with Epstein-Barr virus-associated lymphoproliferative disorder (EBV LPD) based on lymphocyte morphology, lymphocyte immunophenotype, and the results of EBV in situ hybridization studies. The differential diagnosis of splenomegaly, with a special emphasis on the sub-Saharan African context, is discussed along with EBV and associated disorders. These cases serve as a call to consider EBV LPD in the differential diagnosis of splenomegaly in children in whom common causes have been ruled out.
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