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Quantitative assessment technique of HyperEye medical system angiography for coronary artery bypass grafting

Masaki Yamamoto1, Hideaki Nishimori2, Takemi Handa2

  • 1Departments of Surgery II and Cardiovascular Control, Kochi Medical School, Kohasu, Oko-cho, Nankoku-shi, Kochi, 783-8505, Japan. y-masaki@kochi-u.ac.jp.

Surgery Today
|June 29, 2016
PubMed

Insights

Quantitative assessment using the HyperEye Medical System (HEMS) with indocyanine green (ICG) can detect coronary artery bypass grafting (CABG) failures. Reduced ICG intensity and acceleration signal potential graft occlusion.

Area of Science:

  • Cardiovascular Surgery
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Coronary artery bypass grafting (CABG) is a critical procedure for treating coronary artery disease.
  • Early detection of graft failure is essential to prevent adverse cardiac events.
  • Indocyanine green (ICG) fluorescence imaging offers potential for real-time graft assessment.

Purpose of the Study:

  • To quantitatively assess the HyperEye Medical System (HEMS) for detecting coronary artery bypass grafts (CABGs) at risk of occlusion.
  • To evaluate the efficacy of ICG-based HEMS in differentiating patent from failed grafts.

Main Methods:

  • HEMS angiograms of 177 grafts from 69 patients undergoing CABG were analyzed.
  • Quantitative metrics including increasing rate of ICG intensity and average acceleration value were measured.
  • Results were compared with fluoroscopic coronary angiography findings.

Main Results:

  • Significant differences in ICG intensity rate and average acceleration value were observed between patent and failed grafts.
  • Failed internal thoracic artery (ITA) and saphenous vein (SV) grafts exhibited lower average acceleration values (71.0 & 91.8 intensity/s² vs. 112.3 & 144.9 intensity/s²).
  • Time to peak luminance intensity did not show significant differences between patent and failed groups.

Conclusions:

  • Quantifiable reductions in ICG intensity rate and average acceleration value are indicative of failed grafts.
  • HEMS provides a quantitative method to detect subtle changes in blood flow, aiding in the early identification of at-risk grafts.
  • This technique may improve post-CABG monitoring and intervention strategies.
Abstract

Keywords:
Coronary artery bypass graftingHyperEye medical SystemIndocyanine green angiographyQuantitative assessment technique

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